The estrogen-replacement drug Premarin, prescribed to menopausal women, is made from horse urine; in fact, the drug’s name is short for PREgnant MARes’ urINe. About 750,000 mares are impregnated each year for the sole purpose of collecting their estrogen-rich urine.
Is Premarin still being produced?
Yet the drug is still made and sold; indeed, the FDA recently gave the manufacturer permission to market a new Premarin-based drug meant to treat osteoporosis as well as menopause.
Is Premarin made from pregnant MARes urine?
The name Premarin was coined from pregnant mare urine, from which the estrogen complex was isolated. Although the complete composition of Premarin and its active components remains undisclosed or unknown, Wyeth reports that it contains a mixture of 10 estrogens.
What happens when you stop taking Premarin?
Once you stop taking estrogen, you may develop brittle bones. However, lifestyle, dietary and nonhormonal medications can be very effective in preventing bone loss and osteoporosis. Women who stop taking HRT may have a lower risk of developing breast cancer.
Why is there no generic for Premarin?
The answer lies in how Premarin is made. The estrogens in Premarin come from—wait for it—the urine of pregnant mares. Since Premarin comes from horse urine, the exact ingredients have not been defined, and the FDA will not approve a synthetic version. Moral of the story: We may never see a Premarin generic.
Does Premarin cause weight gain?
There is no evidence that HRT leads to weight gain or weight loss. Women typically undergo menopause between the ages of 45 and 55. It occurs around one year after a woman’s last menstrual cycle. The menopausal transition affects the production of hormones produced by the ovaries.
When was Premarin taken off the market?
Then, in 1991, the FDA withdrew their approval of less-expensive, generic estrogen products. It’s complicated, but their reasoning went like this: Premarin, itself, is a mixture of at least 50 chemically different estrogen compounds.
What does Premarin do to your body?
PREMARIN is a type of treatment called hormone replacement therapy (HRT) and contains the hormone estrogen in the form known as conjugated estrogens. PREMARIN helps to relieve the discomfort many women feel during and after menopause, including symptoms such as “hot flushes”, sweating and vaginal dryness.
Will Premarin affect my husband?
A: According to the North American Menopause Society, Estrace or other vaginal creams (Premarin) should not be used right before sex because the partner may absorb the estrogen hormone through his skin (Journal of Reproductive Medicine, January 2008). Over time, estrogen could have a feminizing effect.
Does Premarin cause dementia?
But after negative reports a decade ago from some large multicenter trials, its use has plummeted. In 2003, one of those trials concluded that dementia incidence among women ages 65-79 who were randomly assigned to PremPro (Premarin plus progestin) was double that of women on placebo.
Is Premarin safe to take?
Premarin may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away. Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries.
What are the side effects of Premarin?
Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
How long does Premarin cream stay in your system?
The average half life (time required for half the active drug to be eliminated from the body) of these metabolites ranges from 11.4 to 26.5 hours. Conjugated estrogens take between two and four weeks to significantly improve menopausal symptoms.
Is estradiol made from horse urine?
Estradiol: One product that is gaining new interest is estradiol, a synthetically produced copy of the estrogen that women’s ovaries make before menopause. While Prempro and Premarin are made from horse urine, estradiol more closely resembles the estrogen that a woman’s body naturally makes.